Integration of diagnostic electrical sensors and their signal transmission in ITER is a combination of the process of physical location within a limited space and complex topology, while accounting for effects on the transmitted signals from the particular local nuclear environment. All components of the signal transmission chain are important. Diagnostic sensors are seen in all parts of the ITER vacuum vessel and transmission lines must cross many functional zones, notably the blanket and the vacuum/pressure boundaries. Effects on the signal emanate from conductor variations (radiation and thermally induced conductivity drift, thermo-electric effects, e-m loading, contact resistance), insulator variations (reduction of voltage stand-off, resistivity degradation, material deposition) and interference (e-m noise, microphony, current and voltage leakage). The particular nuclear aspects to be addressed are the high first wall photon flux, the high fast neutron and gamma fluxes, and high neutron fluence. Designs have been developed for the integration of sensors and their connecting wiring within the vacuum vessel, shielding blanket, divertor cassettes and port structures. These are presented here, considering first the radiation effects, then the integration of the diagnostic sensors, the transmission routes and finally the transmission hardware.