Enabling 3D X-ray imaging at very low dose
  • European Union
  • VOXEL is Horizon2020 RIA-FET-OPEN Grant Number: 665207

VOXEL - Volumetric medical X-ray imaging at extremely low dose

Computerized Tomography (CT) has been one of the greatest achievements in medical imaging, but at the cost of a high, potentially harmful, X-ray irradiation dose. The ultimate goal of VOXEL is to provide an alternative to tomography with a disruptive technology enabling 3D X-ray imaging at very low dose. VOXEL aims at prototyping new cameras working either in the soft or hard X-rays that will combine the X-ray penetration and nanometre spatial resolution, easiness to use, afforded by avoiding the rotation of the source or the sample, and extremely low dose for maximum impact on medicine and biology.

VOXEL relies on the integration of trans-disciplinary fields in medical imaging, optics, X-ray physics, computational and applied mathematics. The VOXEL team members are experts in X-ray metrology, wavefront sensing, atomic physic, mathematical computing and 3D medical imaging. By basing the research lead in Portugal with a woman coordinator, VOXEL will be transformative for scientifically emerging countries.

VOXEL Project Team


VOXEL is an international project, with partners from Portugal, Spain, France, Italy, and the Netherlands. You can find a short description of all the VOXEL partners below.

Instituto Superior Técnico

The Association of Instituto Superior Técnico for Research and Development (IST-ID) is a private not-for-profit institution, which primarily aims at carrying out Science and Technology activities, fostering knowledge transfer and promoting the involvement of national and foreign researchers, internally and externally, in RD&I projects in their areas of expertise.

Laboratoire d'Optique Appliquée

Laboratoire d'Optique Appliquée (LOA) is a public French laboratory under three institutions CNRS, Ecole Nationale Supérieure des Techniques Avancées-ParisTech and Ecole Polytechnique. The LOA is composed of about 100 persons on which half have permanent positions.

Universidad Politecnica Madrid

The Universidad Politécnica de Madrid (UPM) celebrates its 33 anniversary this year 2014. Despite the recent foundation of this university, most of its centres are over hundred years old and were founded during the 18th and 19th century. They were independent schools until they were grouped to form the UPM. It is no exaggeration to state that over one and a half centuries great part of the history of Spanish technology has been written by the Schools of Architecture and Engineering.


The Laboratoire Interactions, Dymanique et Lasers (LIDYL) laboratory is dedicated to Ultrafast Science research. The laboratory belongs to the IRAMIS (Institut Rayonnement Matière de Saclay) institute devoted to fundamental research at the CEA (Commissariat à l'Energie Atomique) research agency. High-intensity laser-matter interaction, laser-driven ultra-short particle sources, femtosecond/attosecond coherent soft X-ray sources, free electron lasers, femtochemistry and development of ultrafast laser diagnostics are among the internationally recognized lines of research at LIDYL.

Centrum Wiskunde & Informatica

Centrum Wiskunde & Informatica (CWI) is the National Research Center for Mathematics and Computer Science in The Netherlands, located in Amsterdam. The Computational Imaging team headed by Prof. Batenburg currently consists of 8 researchers involved in large-scale inverse problems in 3D and 4D (time-resolved) imaging. The group covers all aspects of the computational imaging pipeline, including data pre-processing, mathematical inverse problems, advanced image reconstruction algorithms, and high performance computation.

Institute of Chemical and Physical Processes (IPCF)

The Rome Unit of the Institute of Chemical and Physical Processes (IPCF) of the Italian National Research Council (CNR) was established in 2010 and forms the IPCF's backbone together with the units located in Messina (IPCF's headquarters), Pisa, Bari and Cosenza. It is based in the Physics Department at Sapienza University, where most of its researchers are housed. Our members carry out experimental and theoretical research in different areas of active matter, soft matter, statistical mechanics and biophysics. The Unit is currently composed of 11 tenured researchers, about twenty research associates from different Italian universities, and three administrative assistants.

Imagine Optic

Imagine Optic is a French firm employing 26 persons full-time; 16 of the are working on R&D. The annual turnover is of 2.5 M€.


  • Experimental demonstration of a collinear triple pulse grazing-incidence pumping scheme for a transient collisional pumped x-ray laser, S. Künzel, G. V. Cojocaru, F. Gärtner, B. Aurand, L. Li, D. Ursescu, Ph. Zeitoun, E .Oliva, B. Zielbauer, T. Kuehl, and M. Fajardo, Journal of Physics B: Atomic, Molecular and Optical Physics 49, pp:215601 (2016), external url: Journal of Physics B: Atomic, Molecular and Optical Physics
  • Wavefront correction in XUV imaging, J. Duarte, COST meeting Athens, (2016)
  • Tips on how to get a FET grant, M. Fajardo, FET Open day, Lisbon, Portugal (2016)


Recent news

The new VOXEL metrology station is ON

January 5, 2017

Around the beginning of 2017, IPFN received a new laser for the VOXEL program (Volumetric medical X-ray imaging at extremely low dose), thanks to the support of the European Commission under the program Horizon2020. The new laser will create an ultra-short and ultra-intense infrared light source, which focused on gases and solid targets like metals, creates x-rays to test the VOXEL camera. These tests will be crucial to calibrate the VOXEL camera prototype.

In a more technical basis, the GoLP team currently has a dual 800 nm laser providing 25 mJ - 40 fs - 10Hz and 7.5 mJ - 30 fs - 1kHz beams on a daily basis. With this configuration, the team hopes to build the X-ray beam lines, which will result toward nice experimental results.

As PI of the GoLP division of the VOXEL program, Marta Fajardo thanked all the involved in the effort, and welcomed all interested in booking a tour to the new facilities.

Virtual unrolling and deciphering of Herculaneum papyri by X-ray phase-contrast tomography

October 24, 2016

More than 1800 carbonized Greek and Latin papyri, discovered at Herculaneum in 18th century, form the unique library survived from antiquity. This unique collection was charred during 79 A.D. Vesuvius eruption, a circumstance which providentially preserved them until now. The goal is to read the text hidden inside unopened papyrus rolls without damaging them. We succeeded in reading the largest portion of Greek text ever detected inside Herculaneum-papyrus rolls using X-ray phase-contrast tomography combined with a set of numerical algorithms for  ‘virtual-unrolling’. We obtained precious information on their probable author, content, ink and on unexpected events historically experienced by them.

The work has been published in Scientific Reports 6, article number: 27227 (2016). The results have had an eco on the media, namely in italian news broadcast and in CNN, which filmed the presentation of this work during the 28th International Congress of Papyrology, (1-6 august 2016 Barcelona, Spain) and is preparing a report to be aired in November 2016.

VOXEL coordinator featured in Spirou

May 5th 2016

Marta Fajardo, coordinator of the VOXEL project, was recently featured in a special number of the Franco-Belgian comics magazine Spirou. In this number of Spirou, Marta Fajardo and some collaborators are seen in the Laser Laboratory L2I of the Institue of Plasmas and Nuclear Fusion (IPFN) @ Técnico Lisboa, Portugal.


April 5th-7th 2017
ASTRA training school, Antwerp, Belgium >
February 6th-8th 2017
ESRF USER MEETING 2017, Grenoble, France
October 3rd-4th 2016
COST WG2 and WG5 meeting, Bucharest, Romania >
September 19th-21st 2016
COST general meeting, Athens, Greece >
June 16th-17th 2016
VOXEL MGT Meeting, CWI, Amsterdam, Netherlands
April 28th-29th 2016
COST WG1 and WG4 meeting, Tallin, Estonia >
April 11th-12th 2016
COST WG3 meeting, Amsterdam, Netherlands >
March 30th-31st 2016
COST WG2 and WG5 meeting, Barcelona, Spain >
January 29th-March 3rd 2016
VOXEL Experiment, CEA, Paris, France
December 15th-17th 2015
VOXEL MGT Meeting, LOA, Paris, France
November 19th 2015
Workshop on 3D Rec, CWI, Amsterdam, Netherlands
October 26th-27th 2015
Workshop on X&XUV optics, Prague, Czech Republic >
September 17th-18th 2015
COST meeting, Upsallla, Sweden >
July 11th-12th 2015
VOXEL MGT Meeting, LOA, Paris, France
July 2nd 2015
VOXEL Kickoff Meeting, Lisbon, Portugal
March 16th-17th 2015
VOXEL MGT Meeting, LOA, Paris, France